Endocrine Abstracts

Backgorund: Adrenal incidentalomas (AI) are lesions discovered incidentally on imaging without clinical symptoms or examination findings. AI can produce hormones in 5-30% of cases. Autonomic cortisol secretion (ACS) is the most common of these. Although ACS is asymptomatic, it increases the risk of metabolic disorders.Methods: Patients aged ≥18 years with adrenal adenoma and upper abdominal MRI who presented and were examined in the endocrinology o...

Introduction: Thyroid carcinoma is common in young women. Radioactive iodine (RAI) therapy has been confirmed as a useful treatment in the management of differentiated thyroid carcinoma (DTC). For women with DTC, the effect of RAI therapy on gonadal and reproductive function is an important consideration. We aimed to evaluate effects of RAI therapy on ovarian function.Method: Women younger than 40 years old and diagnosed with thyroid cancer that required...

Background: The characteristics of multifocal PTC remain controversial. Surgical approach to multifocal tumor changes between centers. In cases that the initial procedure was lobectomy, most clinicians would suggest for completion thyroidectomy since the risk of PTC in the contralateral lobe is significant. This study aimed to evaluate the incidence of bilateral involvement, predictive factors for bilaterality and whether or not bilaterality was related with more aggressive hi...

Background: Differential diagnosis of a thyroid nodule is difficult if it is a follicular lesion. Follicular lesions include follicular adenoma (FA) or a malign neoplasm (follicular cancer (FC) or follicular variant of papillary thyroid carcinoma (FVPTC)). Cytology can’t separate benign from malignant condition in follicular lesions. Differential diagnosis is important because patients often undergo less than ideal interventions, such as a total thyroidectomy for a benign...

Introduction: Endocrinological and metabolic changes can occur in critically ill patients, which may affect the prognosis and outcome. The hypothalamic–anterior–pituitary axis (HPA) plays a crucial role in the endocrine regulation of metabolic and immunological homeostasis. In this prospective study, we evaluated the pituitary–adrenal–gonadal–thyroid axis in the adult Intensive Care Unit (ICU) patients,their outcome, the association between these hormo...

Introduction: Xantoma disseminatum (XD) is a rare non-Langerhans cell histiocytosis (NLCH) which is often resistant to treatment. In this report, we presented a case with extensive cutaneous, hypothalamohypophysial, cerebral and gastrointestinal system involvement, which responded well to cyclophosphamide.Case: A 16-year-old female patient admitted to our hospital with the complaints of amenorrhoea, weight gain, polidipsia, poliuria, yellow-brownish papu...

Case: A 30-year-old man with hypoparathyroidism has been treated with calcitriol and calcium for 2 years, admitted hospital with persisting diarrhea. An endoscopic operation is planned. But when he was waiting for this examination as outpatient condition, he had a convulsion and had been taken in hospital by parents. Initial laboratory analyses revealed that he was hypocalcemic (total calcium of 6 mg/dl) and parathormone (PTH) 8 pg/ml, phosphorus 5.7 mg/dl, and magnesium 2 mg/...

Background: Prolactin secreting pituitary adenomas (prolactinomas) is the most common pituitary adenoma. The magnitude of prolactin secretion in prolactinomas is usually proportionate to the tumor’s size. Invasive giant prolactinoma is a large prolactinoma (>4 cm in dimension) presenting with serum prolactin levels of >1000 ng/ml and mass related clinical symptoms. Giant prolactinoma is rare and usually presents in men.Case report: A 52-year...

Case: A 63-year-old acromegalic woman admitted hospital for lassitude and dizziness. She has been diagnosed acromegaly 10 years ago and had two transsphenoidal operations. Remission wasn’t achieved. Then she started to use lanreotide (somatostatin analogue) and for 7 years she has been treated with it. In laboratory examination, basal plasma GH 1.21 ng/ml (NR:0–5); nadir GH level after glucose tolerance test, 1.2 ng/ml (NR: less than 1); IGF1, 129.1 ng/ml (NR: for ag...

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder that is characterized by hypercalcemia and elevated or normal levels of parathyroid hormone (PTH). Most PHPT cases are incidentally discovered when routine laboratory analysis reveals hypercalcemia. PHPT should be considered in any person with elevated serum calcium (Ca) levels and no clear evidence of malignancy. Serum phosphorus (P) is low due to the phosphaturic effects of PTH and mostly in the ...